512 Tetraoxanes induced ROS production and activation of caspase 3 in HeLa cells
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چکیده
منابع مشابه
Caspase 3 is activated through caspase 8 instead of caspase 9 during H2O2-induced apoptosis in HeLa cells.
Oxidative stress is known to be involved in a variety of pathological processes including atherosclerosis, diabetes, and neurodegenerative diseases. Understanding how intracellular signaling pathways respond to oxidative stress will have a significant implication in the therapy of these diseases. In this study, we applied hydrogen peroxide (H(2)O(2)) to trigger apoptosis and investigated the dy...
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Sulforaphane (SFN) is an isothiocyanate that is found in abundant quantities in many cruciferous vegetables including broccoli and cauliflower. Its inhibitory effects on tumor cell growth in vitro and in vivo, which is dependent on the direct effect on cancer cells, has attracted considerable attention. This study examined the effects of SFN on the growth of human cervical carcinoma HeLa and he...
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BACKGROUND At least half of all cases of early onset (<60) familial Alzheimer's disease (FAD) are caused by any of over 150 mutations in three genes: the amyloid precursor protein (APP), presenilin 1 (PS1), and presenilin 2 (PS2). Mutant forms of PS1 have been shown to sensitize cells to apoptotic cell death. OBJECTIVE We investigated the effects of hypocapnia, a risk factor for both cognitiv...
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Aims: The biosynthesis of nanoparticles is widely considered today. The aim of this investigation was the biosynthesis and coating of Ag.NPs with Zataria multiflora (Zm-Ag.NPs) leaf extract and assess its apoptosis promoting effects. Methods: The Zm-Ag.NPs was characterized by UV-visible and FTIR spectroscopy, TEM, EDS, DLS and measurement of zeta-potential. Apoptosis induction effects of Zm-A...
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ژورنال
عنوان ژورنال: European Journal of Cancer Supplements
سال: 2010
ISSN: 1359-6349
DOI: 10.1016/s1359-6349(10)71313-6